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Karri, Veera Venkata Satyanarayana Reddy
- Curcumin Loaded Ethosomal Vesicular Drug Delivery System for the Treatment of Melanoma Skin Cancer
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Authors
Radha Krishna Kollipara
1,
Vyshnavi Tallapaneni
1,
Bharat Kumar Reddy Sanapalli
1,
G. Vinoth Kumar
1,
Veera Venkata Satyanarayana Reddy Karri
1
Affiliations
1 Department of Pharmaceutics, JSS College of Pharmacy, Ootacamund, JSS Academy of Higher Education and Research, Mysuru, Karnataka, IN
1 Department of Pharmaceutics, JSS College of Pharmacy, Ootacamund, JSS Academy of Higher Education and Research, Mysuru, Karnataka, IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 4 (2019), Pagination: 1783-1792Abstract
Curcumin has an excellent safety profile having various pleiotropic actions, including anti-inflammatory, antioxidant, antitumoral, anticancer, and antimicrobial activities, with the potential for neuroprotective activity but the poor oral bioavailability limits its use as oral dosage form. The purpose of this study was to formulate and evaluate the transdermal drug delivery system of Ethosomes containing curcumin, a potent anti-cancer drug. Study on various formulation excipients revealed that all the excipients shown some variation which affected the vesicle size, zeta potential, PDI and entrapment efficiency. Batch prepared with 10 % of soya lecithin, 4.5 % of ethanol and 10% of cholesterol showed maximum entrapment efficiency of 81.2±3.12.In in vitro drug permeation studies using dialysis bag, the samples withdrawn in equal time intervals shown more drug release from the dialysis bag in comparison with that of inhouse paclitaxel gel which conform that the curcumin loaded ethosomal gel is a better formulation for the further studies. In ex vivo, permeation study using pork ear skin, curcumin loaded ethosomal gel showed the greater drug deposition on the skin > 60 % in 12 hrs for the better curability for the melanoma. Whereas inhouse paclitaxel gel shown < 60 % of drug deposition in 12 h. The comparison of both ethosomal gel and inhouse paclitaxel gel reveals that ethosomal gel shown maximum release within 12 hrs in both in vitro and ex vivo studies, which can be taken for the further in vitro cell line and in vivo study.Keywords
Curcumin, Anticancer, Ethosomes, Melanoma, PDI.References
- E. Touitou, N. Dayan, L. Bergelson, B. Godin, M. Eliaz, Ethosomes — novel vesicular carriers for enhanced delivery: characterization and skin penetration properties Journal of Controlled Release 65 (2000) 403–418
- Donatella Paolino, Giuseppe Lucania, Domenico Mardente, Franco Alhaique, Massimo Fresta, Ethosomes for skin delivery of ammonium glycyrrhizinate: In vitro percutaneous permeation through human skin and in vivo anti-inflammatory activity on human volunteers Journal of Controlled Release 106 (2005) 99–110
- Cavalli, R., Marengo, E., Rodriguez, L., and Gasco, M. R. (1996). Effects of some experimental factors on the production process of solid lipid nanoparticles. European journal of pharmaceutics and biopharmaceutics, 42(2), 110-115.
- Chen, Y. J., Jinetal. (2006). [Preparation of solid lipid nanoparticles loaded with Xionggui powder-supercritical carbon dioxide fluid extraction and their evaluation in vitro release]. Zhongguo Zhong yao za zhi= Zhongguozhongyaozazhi= China journal of Chinese Materia Medica, 31(5), 376-379.
- Elldem, T., Speiser, P., and Hineal, A. (1991). Optimization of spray-dried and congealed lipid microparticles and cha-racterization of their surface morphology by scanning electron microscopy. Pharm Res, 8, 47-54.
- Ducat, E.etal. (2010). The experimental design as practical approach to develop and optimize a formulation of peptide-loaded liposomes. AAPS Pharm Sci Tech, 11(2), 966-975.
- Bhattacharyya, S,P. et al. (2012). Flurbiprofen loaded solid lipid nanoparticle formulation and optimization by using response surface methodology. International Journal of Pharmacy and Pharmaceutical Sciences, 4.
- Ankita, S., Bharakada, V., Rajesh, Ks., Jha, Ll. (2013). Experimental design and optimization studies of thermoreversible hydrogel containing liposomes for the controlled delivery of 5-fluoro uracil. Pharmagene, 1, 24-32.
- Avadi, Mr. et al. (2010). Preparation and characterization of insulin nanoparticles using chitosan and Arabic gum with ionic gelation method. Nanomed-Nanotechnol, 6, 58-63.
- Simvastatin Loaded Polycaprolactone-Collagen Scaffolds for the treatment of Diabetic Foot Ulcer
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Authors
Affiliations
1 Department of Pharmaceutics, JSS College of Pharmacy, Ooty, IN
1 Department of Pharmaceutics, JSS College of Pharmacy, Ooty, IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 6 (2019), Pagination: 2637-2644Abstract
Scaffolds are the adaptable tools for the treatment of diabetic wounds, In this study, Simvastatin was loaded in polycaprolactone-collagen scaffolds for the treatment of diabetic foot ulcer using the freeze-drying technique. Eventually scaffolds characterization were observed in terms of Scanning Electron Microscopy, Differential scanning calorimetry (DSC), Porosity, Water absorption test, Matrix degradation, In vitro drug release studies, cell proliferation assay, cytotoxicity assay. Scaffolds prepared with polycaprolactone and collagen-polymer showed the homogeneous distribution with high porosity, extended biodegradation rate, high water uptake. All the scaffold formulation showed the sustained drug release and then a plateau. The cross-Linked scaffold has significant slower release in comparison to non-crosslinked scaffold, this is because of cross-linking of the scaffolds where the chemical and mechanical bonding is high compared to non-crosslinked scaffold, Non-crosslinked, showed 85.34% of drug release by this it can be concluded that non cross-linked scaffolds showed the prolonged release, In the cell proliferation assay after 72 h, the cell growth was found to be greater when we compared with placebo and control due to the presence of drug, which explains that the cells are in logarithmic phase. Noncross linked scaffold has shown an increase in cell growth by 28% from its initial value. In Differential Scanning Calorimetry (DSC) shows that there is no change in the peaks by that we can confirm that all the excipients are compatible to each other The obtained results imply that the investigated scaffold is a potential candidate for skin regeneration application because the present study states that simvastatin is having all the properties to treat the Diabetic Foot Ulcer(DFU) without producing the resistance.Keywords
Simvastatin, Polycaprolactone, Collagen, Composite Scaffolds, Diabetic Wounds.References
- Karri VVSR, Kuppusamy G, Talluri SV, Yamjala K, Mannemala SS, Malayandi R. Current and emerging therapies in the management of diabetic foot ulcers. Curr Med Res Opin [Internet]. 2016;32(3):519–42. Available from: http://www.tandfonline.com/doi/full/10.1185/03007995.2015.1128888
- Landén NX, Li D, Ståhle M. Transition from inflammation to proliferation: a critical step during wound healing. Cell Mol Life Sci. 2016;73(20):3861–85.
- Mahmoud AA, Salama AH. Norfloxacin-loaded collagen/chitosan scaffolds for skin reconstruction: Preparation, evaluation and in-vivo wound healing assessment. Eur J Pharm Sci [Internet]. 2016; 83:155–65. Available from: http://dx.doi.org/10.1016/j.ejps.2015.12.026
- Mir M, Najabat M, Afifa A, Ayesha B, Munam G, Shizza A. Synthetic polymeric biomaterials for wound healing: a review. Prog Biomater [Internet]. 2018; (Mostow 1994). Available from: https://doi.org/10.1007/s40204-018-0083-4
- Cínthia A, Irami R, Filho A, Damasceno BPGL, Sócrates E, Egito T. Simvastatin improves the healing of infected skin wounds of rats 1 A Simvastatina melhora a cicatrização de feridas infectadas da pele de ratos. 2007;22(Supplement 1):57–63.
- Farsaei S, Khalili H, Farboud ES. Potential role of statins on wound healing: review of the literature. 2012;238–47.
- Baxter R, Hastings N, Law a., Glass EJ. [ No Title]. Anim Genet. 2008;39(5):561–3.
- Thangavel P, Ramachandran B, Muthuvijayan V. Fabrication of chitosan / gallic acid 3D microporous scaffold for tissue engineering applications. 2015;750–60.
- Sultana N, Khan TH. Water absorption and diffusion characteristics of nanohydroxyapatite (nHA) and poly(hydroxybutyrate-co-hydroxyvalerate-) based composite tissue engineering scaffolds and nonporous thin films. J Nanomater. 2013;2013.
- Kumar PTS, Srinivasan S, Lakshmanan V, Tamura H, Nair S V, Jayakumar R.  -Chitin hydrogel / nano hydroxyapatite composite scaffolds for tissue engineering applications. Carbohydr Polym [Internet]. 2011;85(3):584–91. Available from: http://dx.doi.org/10.1016/j. carbpol.2011.03.018
- Sun X, Wang J, Wang Y, Zhang Q. Collagen-based porous scaffolds containing PLGA microspheres for controlled kartogenin release in cartilage tissue engineering. Artif Cells, Nanomedicine, Biotechnol [Internet]. 2017;0(0):1–10. Available from: https://doi.org/10.1080/21691401.2017.1397000
- Vernon RB, Gooden MD, Lara SL, Wight TN. Microgrooved fibrillar collagen membranes as scaffolds for cell support and alignment. 2005; 26:3131–40.
- Demirci S, Doğan A, Demirci Y, Şahin F. In vitro wound healing activity of methanol extract of Verbascum speciosum. 2014;7(3):37–44.
- Saurabh Mehta. Review of Heterocyclic Scaffolds for the Inhibitors of ATP synthase. Asian J. Research Chem. 2018; 11(2):505-508.
- Radhika G, Sreelakshmi Divya P, Prashanth Reddy G, Venkatesh P, Ravindra Reddy K. An Overview on Regenerative Medicine. Research J. Pharm. and Tech.3 (3): July-Sept. 2010; Page 727-728.
- Hisham A. Abbas. Diabetic Foot Infection. Research J. Pharm. and Tech. 8(5): May, 2015; Page 575-579.
- P. Maheshwari, D. Pavithra, Neethu. T. T, T.S. Shanmugarajan, P. Shanmugasundaram. Study on Health Outcomes in Diabetic Patients - Association Between Diabetic Foot Ulcer and Psychological Distress. Research J. Pharm. and Tech. 2017; 10(1): 44-48.
- Radhika Chelamalla, Ajitha Makula. Molecular docking studies and ADMET Predictions of Pyrimidine Coumarin Scaffolds as Potential IDO Inhibitors. Asian J. Research Chem. 2017; 10(3):331-340.
- Bonshikachatterjee, Nivetha. A, Mohanasrinivasan. V. Immobilization of β-galactosidase in Chitosan-Alginate composite scaffolds and optimization of lactose hydrolysis. Research J. Pharm. and Tech 2018; 11(4): 1480-1485.
- Smriti Agarwal, Vinayak Jhunjhunwala, G. Priya. Fabrication and Morphological Analysis of Gelatin-Alginate Scaffolds. Research J. Pharm. and Tech 2018; 11(9): 3816-3818.
- Saumya S, Agila Anbuselvan, Poorva S, G. Priya. A Review on 3D Printing Techniques and Scaffolds for Auricular Cartilage Reconstruction. Research J. Pharm. and Tech 2018; 11(9): 4179-4186
- Keerthic Aswin S, Jothishwar S, Visvavela Chellaih Nayagam P, G. Priya. Scaffolds for Biomolecule Delivery and Controlled Release–A Review. Research J. Pharm. and Tech 2018; 11(10): 4719-4730.
- Hisham A. Abbas, Mona A. El-Sayed, Laila M. Al-Kadi, Amany I. Gad. Diabetic foot infections in Zagazig University Hospital: bacterial etiology, antimicrobial resistance and biofilm formation. Research J. Pharm. and Tech. 7(7): July 2014 Page 783-788
- P. Maheshwari, D. Pavithra, Neethu. T. T, T.S. Shanmugarajan, P. Shanmugasundaram. Study on Health Outcomes in Diabetic Patients - Association Between Diabetic Foot Ulcer and Psychological Distress. Research J. Pharm. and Tech. 2017; 10(1): 44-48.
- Robson MC, Mustoe TA, Hunt TK. The future recombinant growth factors in wound healing. Am J Surg 1998;2(suppl 1):80-2S